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Papel del citocromo c en la respiración celular y regulación por modificaciones postraduccionales

Authors: Conejero Guillén, Andrés;

Papel del citocromo c en la respiración celular y regulación por modificaciones postraduccionales

Abstract

El citocromo c es una proteína pequeña y globular cuya función principal consiste en actuar como un transportador electrónico móvil entre los complejos III y IV de la cadena de transporte de electrones mitocondrial. Asimismo, se encuentra aparentemente implicado en la estabilidad estructural de los complejos mitocondriales I, III y IV y posiblemente también en la estabilidad estructural de los supercomplejos mitocondriales. El citocromo c se considera actualmente una proteína multifuncional de clave importancia para la homeostasis celular, que, además de sus funciones en la fosforilación oxidativa, se encuentra implicada en procesos como la apoptosis y potencialmente en la respuesta al daño en el DNA. El presente trabajo analizará el papel del citocromo c en el metabolismo energético y cómo el mismo se regula mediante diferentes modificaciones postraduccionales, las cuales alteran la funcionalidad de la proteína. Asimismo, se describirán los mecanismos de transferencia electrónica del citocromo c.

Universidad de Sevilla. Grado en Biología

Country
Spain
Related Organizations
Keywords

citocromo c oxidasa, fosforilación oxidativa, mitocondria, metabolismo energético, Complejo IV, metabolismo redox, catabolismo, citocromo c1, Grupo hemo, Citocromo c, cadena de transporte de electrones mitocondrial, Fosforilación oxidativa, citocromo c, complejo III, metaloproteína, hemoproteína, Metabolismo energético, Citocromo c oxidasa, Mitocondria, complejo IV, Citocromo c1, modificaciones postraduccionales, Metabolismo redox, Citocromo, cadena respiratoria, hemo, Respiración celular, cadena de transporte de electrones mitocondrial; cadena respiratoria; catabolismo; citocromo; citocromo bc1; citocromo c; citocromo c oxidasa; citocromo c1; complejo III; complejo IV; fosforilación oxidativa; grupo hemo; hemo; hemoproteína; metabolismo energético; metabolismo redox; metaloproteína; mitocondria; modificaciones postraduccionales; respiración celular, Complejo III, citocromo, citocromo bc1, Cadena de transporte de electrones mitocondrial, Citocromo bc1, respiración celular, Cadena respiratoria, Hemoproteína, Modificaciones postraduccionales, Hemo, Metaloproteína, grupo hemo, Catabolismo

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
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