Bone loss. Therapeutic approaches for preventing bone loss in inflammatory arthritis.
Copyright policy )Bone loss. Therapeutic approaches for preventing bone loss in inflammatory arthritis.
Inflammatory arthritides are commonly characterized by localized and generalized bone loss. Localized bone loss in the form of joint erosions and periarticular osteopenia is a hallmark of rheumatoid arthritis, the prototype of inflammatory arthritis. Recent studies have highlighted the importance of receptor activator of nuclear factor-kappa B ligand (RANKL)-dependent osteoclast activation by inflammatory cells and subsequent bone loss. In this article, we review the pathogenesis of inflammatory bone loss and explore the possible therapeutic interventions to prevent it.
- University of California United States
- University of California United States
- University of California, San Francisco United States
rheumatoid arthritis, Aging, Clinical Sciences, Immunology, Osteoclasts, receptor activator of nuclear factor-kappa B ligand, Clinical sciences, Review, Autoimmune Disease, Arthritis, Rheumatoid, Rheumatoid, 2.1 Biological and endogenous factors, Humans, Aetiology, Membrane Glycoproteins, Biomedical and Clinical Sciences, Receptor Activator of Nuclear Factor-kappa B, Arthritis, Prevention, Inflammatory and immune system, RANK Ligand, Arthritis & Rheumatology, osteoprotegerin, Musculoskeletal, osteoclast, Public Health and Health Services, Osteoporosis, Bone Remodeling, Carrier Proteins
rheumatoid arthritis, Aging, Clinical Sciences, Immunology, Osteoclasts, receptor activator of nuclear factor-kappa B ligand, Clinical sciences, Review, Autoimmune Disease, Arthritis, Rheumatoid, Rheumatoid, 2.1 Biological and endogenous factors, Humans, Aetiology, Membrane Glycoproteins, Biomedical and Clinical Sciences, Receptor Activator of Nuclear Factor-kappa B, Arthritis, Prevention, Inflammatory and immune system, RANK Ligand, Arthritis & Rheumatology, osteoprotegerin, Musculoskeletal, osteoclast, Public Health and Health Services, Osteoporosis, Bone Remodeling, Carrier Proteins
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