?-Caryophyllene and longifolene are sesquiterpenes with characteristic aroma properties, which are primary constituents of essential oils and important ingredients commonly used in food, perfumery, cosmetics, detergents and pharmaceuticals, which create a worldwide market. ?-Caryophyllene and longifolene were converted through microbial biotransformation by using Wolfiporia extensa to a mixture of products over seven days at 25o C to be evaluated as potential aroma and antimicrobial agents. The characterization of transformation products was carried out by comparison of their GC-MS spectra and retention indices with that of published data (Wiley, NIST and ADAMS databases). As a result, microbial transformation reactions produced various volatile compounds mainly consisting of ketones, aldehydes and alcohol-bearing derivatives of ?-caryophyllene and longifolene. © 2019, Badebio Biotechnololgy Ltd. All rights reserved.