In recent years, research conducted in the US and in Italy has demon strated production of radioiso topes in plasma focus de vices, and particularly, on what could be termed “endogenous” production, to wit, production within the plasma it self, as opposed to irradiation of tar gets. This technique re lies on the formation of localized small plasma zones characterized by very high densities and fairly high temperatures. The conditions prevailing in these zones lead to high nuclear reaction rates, as pointed out in previous work by several authors. Further investigation of the cross sections involved has proven necessary to model the phenomena involved. In this pa - per, the present status of research in this field is reviewed, both with regards to cross section models and to experimental production of radio isotopes. Possible out comes and further development are discussed.