In the last two centuries chemistry has improved our quality of life through the production of thousands of useful products and materials, but this achievement comes at an environmental price. Green chemistry and its principle want to reduce or eliminate the negative environmental impacts and through design, innovation and new processes to restore the planet’s sustainable development. The term “Green Analytical Chemistry”, proposed by J. Namieśnik in the early 2000, at the beginning was scarcely employed in the analytical chemistry community in contrast with green catalyst development and green organic chemistry concepts. Nonetheless, efforts made in analytical chemistry in the past 10 years have led to the adaptation of existing methods and development of new techniques to save time and chemicals, and to improve overall performance in agreement with the green chemistry principles. It seems straightforward to consider green analytical chemistry as that part of the green chemistry devoted to analysis. The impact of the application of green principles to analytical chemistry can be easily realized by considering the number of analysis required around the world to control our health, the quality and safety of all kinds of products and to monitor the environment. In fact, it is well known that analysis requires employment of a great amount of chemicals and energy and it provides some collateral risks for both, operators and the environment, due to the use of toxic reagents and solvents and the generation of dangerous wastes. In this keynote lecture, some of the main tools to greening analytical procedures will be revised. In particular, the talk will focus on the efforts required for improving the analytical practices in order to minimize adverse effects such as: the replacement of toxic solvents and reagents by safer ones, the miniaturization of analytical procedures with a resulting reduction in the waste production and analysis time, the strong reduction of the analytical steps or the analysis of untreated samples. All of these steps are significant parts of methodologies that could contribute to improve the safety of analytical procedures and to minimize environmental dangers. Moreover, as green analytical chemistry procedures have to maintain and/or improve the quality of analytical data, chemometric aspects will be examined. In particular multiparametric measurements and remote sensing methodology able to enhance the information obtained with reduced analytical task will be discussed.