The research program is aimed at preparing and testing organocatalytic packed-bed microreactors to prove the potential benefits arising from the combination of the above synthetic methodology and production technology. This program is currently being developed on the basis of the following general thread: i) heterogeneization of a successful asymmetric organocatalyst on silica and optimization of its performance under batch conditions; ii) preparation of the corresponding packed-bed microreactor and preliminary testing in continuous-flow regime; iii) development of a suitable in-line analysis method, and iv) final optimization of the continuous-flow process based on kinetic and thermodynamic characterization thereof.