Neurobiological Aspects of Ethanol-Derived Salsolinol in NEUROSCIENCE OF ALCOHOL: Mechanisms and Treatment
Neurobiological Aspects of Ethanol-Derived Salsolinol in NEUROSCIENCE OF ALCOHOL: Mechanisms and Treatment
SUMMARY POINTS 1. Ethanol acts through glutamate and GABA, but indirectly necessitates dopamine, opioid peptides, adenosine, and serotonin neurotransmission. 2. Ethanol acts through the involvement of ethanol- derived acetaldehyde. 3. Acetaldehyde is a highly reactive, electrophilic molecule. 4. Tetrahydroisoquinolines are the acetaldehyde’s condensation products with biogenic monoamines. 5. Salsolinol, the condensation product of acetaldehyde and dopamine, has been implicated in the neurobiological basis of alcoholism and in the emergence of neurological disorders. 6. Ethanol may act both as a pro-drug and a pro-toxic agent.
- University of Sassari Italy
1,2-dimethyl-6,7-dihydroxyisoquinolinium ion, Acetaldehyde, Ethanol, Ethanol’s metabolism, N-methyl-salsolinol, Neurotoxicity, Salsolinol, Tetrahydroisoquinolines
1,2-dimethyl-6,7-dihydroxyisoquinolinium ion, Acetaldehyde, Ethanol, Ethanol’s metabolism, N-methyl-salsolinol, Neurotoxicity, Salsolinol, Tetrahydroisoquinolines
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