The aim of this work was to evaluate the possible beneficial effects of a nutraceutical diet on a careless dermal melanoma in an elderly dog. Hemato-biochemical and metabolic parameters as well as clinical symptoms evaluations were performed to monitor the possible improvements of the clinical picture of the dog following a nutraceutical diet supplementation. Hematobiochemical analyzes and clinical symptoms before nutraceutical diet and after specific diet suspension showed an overall improvement.Moreover, no strong evidence ofmetastasis after radiographic investigations was observed. This study suggests that clinical statusand quality of life (QoL) of an elderly dog affected by dermal melanoma can be positively influenced by a nutraceutical diet supplementation.