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The foreign body reaction

Authors: Putten, Sander van;

The foreign body reaction

Abstract

Biomaterialen worden wereldwijd veel gebruikt, bijvoorbeeld voor het repareren, herstellen en beschadigen van beschadigd of ziek weefsel. Het lichaam reageert op deze biomaterialen met een ontstekingsreactie die de ‘foreign body reaction’ (FBR) wordt genoemd. Wanneer het lichaam biomaterialen niet verdraagt, kan dat grote gevolgen hebben. Daarom wordt veel onderzoek verricht naar de FBR. Van Putten stelt dat veel onderzoek gestuurd wordt door aannames en hypothesen die nog bewezen moeten worden. Hij pleit daarom voor meer fundamenteel onderzoek naar de cellulaire en moleculaire processen die de FBR sturen, en levert daaraan zelf in zijn proefschrift een bijdrage. Een van zijn conclusies is dat de aanwezigheid van endotoxines, celwandbestanddelen van gram-negatieve bacteriën, in biomaterialen de lichaamsreactie kan beïnvloeden. Ook concludeert hij dat de FBR gemoduleerd kan worden door gebruik te maken van de menselijke cytokine (een molecuul die een rol speelt in de immuunafweer) Interleukine-10.

Country
Netherlands
Related Organizations
Keywords

Immuunreacties, Immuunmodulatie, Macrofagen, Extracellulaire $matrix, Biomaterialen, immunologie (geneeskunde), Proefschriften (vorm), Fibroblasten, Lipopolysacchariden, Xenobiotica, Ontstekingen (geneeskunde)

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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