CRO National Cancer Institute Aviano have developed different repositories overtime to fit with the different library users needs: scientific output assessment or attendants access to the educational resources. These repositories lacks of overall integration and interoperability. Sometimes archives overlap or use different metadata standards. This affects the interoperability with other archives and the persistence of data. These data need to be managed and disclosed to other institutions, professionals and laymen as well. The CRO Scientific and Patients library in collaboration with University of Trieste developed CRO OpenDocuments (COD), the Institutional Repository for scientific and educational resources. COD has been developed exploiting DSpace-CRIS: chosen for its unique features like metadata standardization (Dublin Core / CERIF oriented), possibility to manage, collect and expose data of all the Research aspects (papers, journals, people, organization units, project...). Following the OpenAIRE Guidelines the interoperability with other archives is granted. We migrated data from the scientific papers, grey literature, CROnews institutional free press, Farmaci&Tumori independent drug bulletin archives. We also included the repository of the Patient Education & Empowerment program resources, specifically addressed to patients. COD had some relevant outcomes in the institution organization: the redefinition of an institutional policy for Open Access and Digital Right management.