The paper describes the new design criteria and control strategies for multi-density dense medium separation (DMS) circuits. The role of the multi-density separation is discussed, and it is emphasized that for many processing problems -related to minerals and coals -it may be very important to perform two or more cuts at different densities in order to obtain a remarkable improvement in quality of products, process efficiency and economy. The two-density separation by dense medium cyclones was generally performed using two dense medium plants in sequence. In contrast to the former technology, the multi-density separation can now be performed by using a single medium circuit composed of different interconnected medium sumps. The sumps, one for each density, are fed with different medium streams selected according to their density, size composition and content in non-magnetic contaminant in such a way that the rheological properties of the media are optimized. This new technology is based on dynamic systems to density the medium, on the size-density segregation of the medium in the cyclones and separating devices and on accurate control systems for the density, viscosity and stability of the dense media of the different sumps. The present paper reports on the theoretical basis for the new, advanced medium circuits and on the systems for the control of the densities and of the rheological properties of the dense media. A typical circuit for a two-density separation is also described, and some industrial applications reported and discussed.