[Metabolism and toxicity of therapeutic chelating agents. 14. Effect of DTPA on hematopoiesis].
Copyright policy )[Metabolism and toxicity of therapeutic chelating agents. 14. Effect of DTPA on hematopoiesis].
By use of 3-H-thymidine it is shown that toxic doses of Ca-DTPA lead to a reversible inhibition of DNA-synthesis in the lymphocytes, erythro- and myelopoietic cells of the rat. The incorporation of 59-Fe into the erythrocytes is markedly imparied. The hematological reaction, i. e. granulocytosis, lympho- and eosinopenia, is ascribed to the general adaptation syndrom. Zn-DTPA proved to be ineffective in all respects.
Iron Radioisotopes, Erythrocytes, Dose-Response Relationship, Drug, Neutrophils, Mitosis, DNA, Pentetic Acid, Tritium, Monocytes, Hematopoiesis, Rats, Eosinophils, Hemoglobins, Zinc, Animals, Calcium, Female, Lymphocytes, Thymidine
Iron Radioisotopes, Erythrocytes, Dose-Response Relationship, Drug, Neutrophils, Mitosis, DNA, Pentetic Acid, Tritium, Monocytes, Hematopoiesis, Rats, Eosinophils, Hemoglobins, Zinc, Animals, Calcium, Female, Lymphocytes, Thymidine
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