PGE2:PGE-2:.
Copyright policy )PGE2:PGE-2:.
The biological activities of 8,12-diiso-PGE2 (ent-11,15-epi-PGE2), PGE2 and PGF2alpha have been compared in a series of pharmacological preparations intended to differentiate between F and E type of activity. Similar to PGF2alpha but unlike PGE2, 8,12-diiso-PGE2 increased the tone of isolated smooth muscle preparations of guinea pig trachea, guinea pig colonic circular layer, rabbit Fallopian tubes. The stimulation effect of 8,12-diiso-PGE2 and PGF2alpha on visceral smooth muscle was also shown in vivo: the two drugs were in all instances able to increase the miogenic activity and tone of rabbit uterus in situ, while these were depressed by PGE2. 8,12-diiso-PGE2 decreased pulmonary compliance and increased pulmonary vascular resistance in the anaesthetized cat; PGE2 always decreased pulmonary vascular resistance, while leaving pulmonary compliance unaltered. The possibility is suggested that 8,12-diiso-PGE2 acts on PGF receptor in different tissues.
Male, Colon, Guinea Pigs, Uterus, Muscle, Smooth, Stimulation, Chemical, Trachea, Depression, Chemical, Muscle Tonus, Cats, Prostaglandins, Animals, Female, Vascular Resistance, Rabbits, Lung, Lung Compliance, Fallopian Tubes
Male, Colon, Guinea Pigs, Uterus, Muscle, Smooth, Stimulation, Chemical, Trachea, Depression, Chemical, Muscle Tonus, Cats, Prostaglandins, Animals, Female, Vascular Resistance, Rabbits, Lung, Lung Compliance, Fallopian Tubes
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