Specific kappa opioid receptor agonists.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2000 English Journal:Farmaco (Societa chimica italiana : 1989), volume 56 (issn: 0014-827X,

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Authors: RONSISVALLE, Giuseppe; MARRAZZO, Agostino; PASQUINUCCI, Lorella Giuseppina; PREZZAVENTO O; PAPPALARDO M; VITTORIO F.;

pmid: 11347952

handle: 20.500.11769/18778 , 20.500.11769/931

Specific kappa opioid receptor agonists.

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Abstract

The results of studies on the design of a heterocyclic scaffold for the dynorphin A pharmacophore and on structure-affinity relationships in the MPCB/CCB series are described. The representative ligands provide insights to binding modes of benzomorphan derivatives to the kappa opioid receptor.

Related Organizations

University of Catania
Italy

Keywords

Analgesics, Opioid, Structure-Activity Relationship, Drug Design, Receptors, Opioid, kappa, Animals, Humans, (−)-cis-N-Normetazocine; Peptidomimetics; Kappa opioid receptor; Kappa opioid agonists, Dynorphins

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