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CuAAC in Protein Conjugation

Authors: la Venia, Agustina; Kovalova, Ana; Vrabel, Milan;

CuAAC in Protein Conjugation

Abstract

This chapter summarizes the use of the copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction in the synthesis of peptide and protein conjugates. The different reaction conditions used for construction of the conjugates and their application in various disciplines are covered. Synthetic strategies for the introduction of the click groups (azide or alkyne) into the peptide backbones are included as well.

Fil: la Venia, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina

Fil: Kovalova, Ana. Czech Academy of Sciences. Institute of Organic Chemistry and Biochemistry; República Checa

Fil: Vrabel, Milan. Czech Academy of Sciences. Institute of Organic Chemistry and Biochemistry; República Checa

Country
Argentina
Keywords

PEPTIDE CONJUGATES, click chemistry, https://purl.org/becyt/ford/1.4, PROTEIN CONJUGATION, CuAAC, https://purl.org/becyt/ford/1

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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