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Article . 2023
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Esporotricosis en Argentina: análisis clínico y epidemiológico Sporotrichosis in Argentina: clinical and epidemiological analysis Esporotricosis en Argentina

Authors: Santiso, Gabriela Maria; Messina, Fernando; Arechavala, Alicia; Marín, Emmanuel; Romero, María de las Mercedes; Sosa, Maria de Los Angeles; Rojas, Florencia Dinorah; +4 Authors

Esporotricosis en Argentina: análisis clínico y epidemiológico Sporotrichosis in Argentina: clinical and epidemiological analysis Esporotricosis en Argentina

Abstract

Introduction. Sporotrichosis is an implantation mycosis caused by Sporothrix spp. It is distributed worldwide and can be found in vegetation and soil. The most frequent route of infection is by trauma with elements contaminated with fungal propagules. Since domestic cats are the most affected animals and can transmit this infection to humans, sporotrichosis is considered a zoonosis. Clinical presentations include nodular lymphangitis, fixed cutaneous, pulmonary (rare), and disseminated (exceptional). Objectives. To analyze the epidemiology of sporotrichosis in Argentina during 2010 and 2022. To describe the clinical presentation, diagnostic methods, and treatment of cases diagnosed during this period. To know the circulating genotypes and to observe possible associations with the geographic location where the infection was acquired. Materials and methods. Analytical, retrospective, and observational study. We analyzed the medical records of patients with sporotrichosis from 12 health institutions in Argentina, between 2010 and 2022. Results. We present 54 cases in which the most frequent clinical form was nodular lymphangitis, and the treatment of choice was itraconazole. Conventional diagnosis was made in all cases. Culture of clinical samples was more sensitive than direct examination because it allowed the isolation of Sporothrix spp. in all 54 cases. Molecular identification was performed in 22 cases, with Sporothrix schenkii sensu stricto being the most frequently isolated species. Conclusions. This study allowed to know the epidemiology of this mycosis in Argentina, as well as the availability of diagnostic methods and the treatment of choice.

Introducción. La esporotricosis es una micosis de implantación causada por Sporothrix spp. Este se encuentra distribuido mundialmente en la vegetación y en el suelo. La ruta más frecuente de adquisición de la enfermedad es por traumatismo con elementos contaminados con propágulos del hongo. Los gatos domésticos son los animales afectados con mayor frecuencia y pueden transmitirla a humanos, por lo que es una zoonosis. Las formas clínicas incluyen la linfangítica nodular, la cutánea fija, la pulmonar es poco habitual y la diseminada es excepcional.Objetivo. Analizar la epidemiología de la esporotricosis en Argentina entre los años 2010 y 2022. Describir la presentación clínica, los métodos de diagnóstico y el tratamiento de los casos diagnosticados en este período. Conocer los genotipos circulantes y observar la relación con el lugar geográfico de adquisición de la infección.Materiales y métodos. Estudio analítico, retrospectivo y observacional por análisis de las historias clínicas de los pacientes con esporotricosis de 12 instituciones de salud de Argentina entre los años 2010 y 2022.Resultados. Se presentan 54 casos. La forma clínica más frecuente fue la linfangítica nodular y el tratamiento de elección el itraconazol. En todos los casos se realizó diagnóstico convencional, siendo el cultivo de los materiales clínicos más sensible que el examen directo, ya que permitió el desarrollo de Sporothrix spp. en los 54 casos. En 22 casos se realizó la identificación molecular y Sporothrix schenkii sensu stricto fue la especie más frecuentemente aislada.

Fil: Rojas, Florencia Dinorah. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina

Fil: Giusiano, Gustavo Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina

Fil: Mussin, Javier Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina

Fil: Romero, María de las Mercedes. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina

Fil: Santiso, Gabriela Maria. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina

Fil: Arechavala, Alicia. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina

Fil: Messina, Fernando. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina

Fil: Marín, Emmanuel. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina

Country
Argentina
Keywords

ARGENTINA, https://purl.org/becyt/ford/3.3, MYCOSES, https://purl.org/becyt/ford/3, SPOROTHRIX, SPOROTRICHOSIS

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green