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CONICET Digital
Article . 2023
License: CC BY NC
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La hipertensión arterial en animales de laboratorio

Authors: Molina Martínez, José Luis; Béquer Mendoza, Leticia; Gómez Hernández, Tahiry; Hernández Moreno, Vicente José; Freire Gómez, Cindy; Pérez Martínez, Daisy;

La hipertensión arterial en animales de laboratorio

Abstract

Las Ciencias Médicas y Biológicas requieren, prioritariamente, que la investigación y la experimentación sean desarrolladas sobre organismos completos (los modelos animales). Su utilización ha permitido desarrollar innumerables ensayos preclínicos para evaluar los mecanismos patógenos y terapéuticos de diversas enfermedades, así como el estudio de las causas, naturaleza y cura de múltiples desórdenes de la salud humana. En este trabajo se muestra una panorámica general de los biomodelos de hipertensión arterial donde se describen: conceptos, características, origen, importancia, utilidad y procedimientos experimentales durante su fase de inducción. También se pondera la justificación de los biomodelos empleados en los estudios preclínicos de esta enfermedad. De igual forma, se describen los antecedentes para medir las alteraciones, las técnicas y los métodos directos e indirectos de medición de la presión arterial, la cual fue provocada experimentalmente en los animales de laboratorio para realizar los estudios de hipertensión humana.

Medical and biological sciences require, as a priority, that research and experimentation be carried out on complete organisms (animal models). Its use has allowed the development of innumerable preclinical tests to evaluate pathogenic and therapeutic mechanisms of various diseases, as well as to study the causes, nature and cure of multiple human health disorders. In this work, we show a general overview of arterial hypertension biomodels where concepts, characteristics, origin, importance, utility and experimental procedures during their induction phase are described. The justification of the biomodels used in preclinical studies of this disease is also considered. Antecedents are also described to measure alterations, techniques and direct and indirect methods of measurement of arterial pressure, which was provoked experimentally in the laboratory animals to carry out the studies of human hypertension.

Fil: Freire Gómez, Cindy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina. Universidad de Ciencias Médicas de Villa Clara.; Cuba

Fil: Hernández Moreno, Vicente José. Universidad de Ciencias Médicas de Villa Clara.; Cuba

Fil: Molina Martínez, José Luis. Universidad de Ciencias Médicas de Villa Clara.; Cuba

Fil: Béquer Mendoza, Leticia. Universidad de Ciencias Médicas de Villa Clara.; Cuba

Fil: Gómez Hernández, Tahiry. Universidad de Ciencias Médicas de Villa Clara.; Cuba

Fil: Pérez Martínez, Daisy. Universidad de Ciencias Médicas de Villa Clara.; Cuba

Country
Argentina
Keywords

MODELOS ANIMALES, FISIOPATOLOGÍA, https://purl.org/becyt/ford/4.3, https://purl.org/becyt/ford/3.1, PRESIÓN ARTERIAL, https://purl.org/becyt/ford/4, https://purl.org/becyt/ford/3, MÉTODOS, HIPERTENSIÓN ARTERIAL, RATA, EXPERIMENTACIÓN ANIMAL, ANIMALES DE LABORATORIO

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green