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CONICET Digital
Article . 2016
License: CC BY NC SA
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Nuevos marcadores electrocardiográficos de hipertrofia ventricular izquierda

Authors: Bonomini, Maria Paula; Ingallina, Fernando Juan; Barone, Valeria; Antonucci, Ricardo; Arini, Pedro David;

Nuevos marcadores electrocardiográficos de hipertrofia ventricular izquierda

Abstract

La hipertrofia ventricular izquierda (HVI) induce cambios en las fases de despolarización y repolarización cardíaca. No obstante, pocos marcadores electrocardiográficos ncluyen parámetros de la repolarización en su diagnóstico. Objetivo de este estudio fue evaluar si la repolarización mejora el diagnóstico electrocardiográfico de la HVI. Material y Métodos: Se estudiamos los vectores QRS y T en el plano horizontal definido por las derivaciones precordiales V1 -V6 y el plano frontal definido por las derivaciones I-aVF en una serie de 40 pacientes con HVI y 34 sujetos control. Resultados: Los índices de HVI se construyeron como combinaciones de parámetros asociados a los vectores de despolarización y repolarización y su rendimiento se comparó con el rendimiento de los criterios de Sokolow-Lyon y Cornell. Los índices que incluyeron parámetros de repolarización mejoraron la sensibilidad de dichos criterios. Sobre los mismos, se construyeron estimativos a partir de medidas directas de amplitud del ECG, con el fin de obtener criterios de fácil medición en la práctica clínica. Para un 90% de especificidad, el mejor criterio, consistiendo en el voltaje de repolarización en la derivación V6 , produjo un 56% de sensibilidad, por encima del 30% de Sokolow-Lyon y el 40% de Cornell. Conclusiones: la repolarización contribuyó al diagnóstico electrocardiográfico de HVI y alentamos la búsqueda de nuevos índices en esta dirección.

Left ventricular hypertrophy (LVH) induces changes in both depolarization and repolarization phases. However, little efforts were made to include repolarization features in its diagnosis. The aim of this study was to evaluate whether the repolarization improves ECG diagnosis of LVH. Methods: To do this, we studied the QRS and T vectors in the horizontal plane (HP) defined by the chest leads V1 -V6 and the frontal plane (PF) defined by the limb leads I-aVF in a series of 40 LVH patients and 34 control subjects. Results: LVH indices were constructed as combinations of parameters associated with depolarization and repolarization vectors and their performance was compared to the performance of Sokolow-Lyon and Cornell. Those indices, which included repolarization parameters, improved the sensitivity of these criteria. The latter were selected to construct estimates from direct measurements of ECG amplitudes, in order to obtain easy measurement criteria in the clinical practice. The best estimate, consisting of the repolarization voltage on lead V6 , produced a 56% sensitivity at 90% specificity, above Sokolow-Lyon (sensitivity 30%) and Cornell (sensitivity 40%). Conclusions: repolarization contributed to the electrocardiographic diagnosis of LVH and we encourage the search for new indices in this direction.

Fil: Arini, Pedro David. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Argentino de Matemática Alberto Calderon; Argentina

Fil: Ingallina, Fernando Juan. Universidad de Buenos Aires; Argentina

Fil: Bonomini, Maria Paula. Universidad de Buenos Aires; Argentina

Fil: Antonucci, Ricardo. Universidad de Buenos Aires; Argentina

Fil: Barone, Valeria. Universidad de Buenos Aires; Argentina

Country
Argentina
Keywords

https://purl.org/becyt/ford/3.2, Left Ventricular Hipertrophy, https://purl.org/becyt/ford/3, Cardiac Vectors, Electrocardiographic Markers

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
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Green