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Part of book or chapter of book . 2021
License: CC BY NC SA
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Metabolismo del Fe-hemocromatosis hereditaria

Authors: Fernández, Juan Manuel;

Metabolismo del Fe-hemocromatosis hereditaria

Abstract

El hierro es esencial para la vida y desde los comienzos de la civilización se utiliza en beneficiosde la salud humana. Por ejemplo, los egipcios, en los años 1500 a.c, lo utilizaban para hacerun ungüento como tratamiento para la calvicie. En la India, en los años 500 a.c, fabricaban diversospreparados basados en hierro como tratamiento de distintas enfermedades. En el año 1713,Lemery y Geoffry comienzan a establecer las bases científicas para el tratamiento de su deficiencia.Más tarde, en 1832, Blaud genera una pastilla a partir de la mezcla de sulfato ferroso ycarbonato de potasio, aunque luego se demostró que esta forma de hierro no se absorbía totalmenteya que lo encontraban en heces. En el año 1920, se demostró que la ingestión de hígadococido era más eficiente que la píldora de Blaud como tratamiento de regeneración de la sangre.Mas tarde (1937) Castle demostró la eficacia del tratamiento con hierro vía parenteral en laanemia hipocrómica. Entre los años 1943 y 1947, se descubre la transferrina, demostrando el rolde la mucosa intestinal en la absorción del hierro. Pocos años después, en 1950, se concluye ydetermina la forma de distribución, metabolismo y balance del hierro y a principios de este siglo,se descubre a la Hepcidina.

Fil: Fernández, Juan Manuel. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigación en Osteospatías y Metabolismo Mineral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina

Country
Argentina
Keywords

Billirrubina, https://purl.org/becyt/ford/3.1, https://purl.org/becyt/ford/3, Hierro

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green