Background: Cancer is a leading cause of child mortality and profoundly affects the psychosocial well-being of both children and their families. There is growing interest in developing cost-effective interventions to support informal caregivers, overcoming geographical and logistical barriers. This study aimed to systematically review evidence on the effectiveness of digital interventions for family caregivers of children and adolescents with cancer, focusing on psychological distress and protective factors such as resilience and coping strategies. Materials and Methods: Following PRISMA guidelines, a systematic review was conducted across five electronic databases (PubMed, Scopus, ProQuest, Web of Science, and CENTRAL). Studies were independently reviewed by a team of three reviewers, and a critical appraisal was performed using Joanna Briggs Institute (JBI) assessment checklists. Results: Nine articles, involving 1,086 caregivers, were included. All studies involved parents acting as primary caregivers. Findings indicate that digital interventions, including online platforms and applications, can significantly reduce symptoms of depression and anxiety with moderate to large effect sizes. Interventions combining psychoeducation, problem-solving, and resilience training showed more promising effects on caregiver adjustment. Future interventions should incorporate interactive resources and involve a multidisciplinary team to enhance effectiveness. Conclusion: This study offers valuable insights for researchers and healthcare professionals, helping identify effective technological solutions to support caregivers in the pediatric oncology setting.