An observation lens is placed on the themes of ethics and on the sustainable approach of the project that operates around the key themes of contemporaneity with an interdisciplinary and transdisciplinary perspective. The focus is to generate a new Taxonomy of contemporary spatial design to respond ethically to the global emergency conditions related to ecological and humanitarian issues, thanks to a new vision and design-driven approaches. The balance or unbalance between Nature and Artifice [biologic and technologic] becomes an interpretative key to identify the prefigurative actions of the design for the spaces in a researched, conscious and experimental ethical, and sustainable vision. The condition of the continuous need for transformation, adaptation, and metamorphosis of contemporary living and environmental systems arises as a central question. As observed by the philosopher Coccia (2020), all living species operate in a conscious way to transform the world around them and adapt it to their own existence. Every natural space is an artificial space. In this sense, in an anti-dialectical ecological perspective, the Technonatures experimental approach understands Nature as a continuous renewal of its capacity for genesis, creation, and adaptation, capable of absorbing the artificial as its component. The notion of Technonatures may provide a fruitful metaphor/myth for motivating discussion and reflection about changing relations between our ecologies, bodies, technologies, and urban worlds. Different Spatial Design Tactics can be studied and activated to achieve new goals for a different Taxonomy in a post-anthropocentric scenario. Tactics that observe the border disciplines and draw useful lessons for the design between humanistic logic, scientific knowledge, transdisciplinary attitudes, observation of nature, and use of the most advanced technologies, where the space designer is part of a cross-disciplinary team, which operates within a design scale of variable intervention, from micro to macro, for a concrete ecological vision of the project towards the post-Anthropocene Era.