Glycopeptides(Vancomycin(VCM), Teicoplanin(TEIC)) are effective against Gram positive cocci(GPC) and mainly prescribing for Methicillin Resistant Staphylococcus aureus(MRSA) infection in Japan. Mode of actions are little bit difference between VCM and TEIC, for example the rate of protein binding, post antibiotic effect and half-life time. Effect of glycopeptide depend on the above MIC. To keep the effective serum concentrations of the drug, recommended the method of loading dose for TEIC and the method of continuous drip infusions for VCM. Also keep the effective serum concentrations shows to shorten the duration of treatment and to protect for development of resistant strains. Biofilm diseases caused by P. aeruginosa, MRSA and MRSE are treated by combination therapy with Fosfomycin(FOM). The most powerful intensive chemotherapy (FOM + Sulbactam/Cefoperazon + Glycopeptides) shows superior effects against multiple infections caused by P. aeruginosa and MRSA.