Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth.
Copyright policy )Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth.
Many solid tumors produce vascular endothelial growth factor C (VEGF-C), and its receptor, VEGFR-3, is expressed in tumor blood vessels. To study the role of VEGF-C in tumorigenesis, we implanted MCF-7 human breast carcinoma cells overexpressing recombinant VEGF-C orthotopically into severe combined immunodeficient mice. VEGF-C increased tumor growth, but unlike VEGF, it had little effect on tumor angiogenesis. Instead, VEGF-C strongly promoted the growth of tumor-associated lymphatic vessels, which in the tumor periphery were commonly infiltrated with the tumor cells. These effects of VEGF-C were inhibited by a soluble VEGFR-3 fusion protein. Our data suggest that VEGF-C facilitates tumor metastasis via the lymphatic vessels and that tumor spread can be inhibited by blocking the interaction between VEGF-C and its receptor.
- University of Helsinki Finland
Neovascularization, Pathologic, Recombinant Fusion Proteins, Transplantation, Heterologous, Vascular Endothelial Growth Factor C, Immunoglobulins, Receptor Protein-Tyrosine Kinases, Breast Neoplasms, Endothelial Growth Factors, Mice, SCID, Transfection, Vascular Endothelial Growth Factor Receptor-3, Lymphatic System, Mice, Animals, Humans, Female, Receptors, Growth Factor, Cell Division, Neoplasm Transplantation
Neovascularization, Pathologic, Recombinant Fusion Proteins, Transplantation, Heterologous, Vascular Endothelial Growth Factor C, Immunoglobulins, Receptor Protein-Tyrosine Kinases, Breast Neoplasms, Endothelial Growth Factors, Mice, SCID, Transfection, Vascular Endothelial Growth Factor Receptor-3, Lymphatic System, Mice, Animals, Humans, Female, Receptors, Growth Factor, Cell Division, Neoplasm Transplantation
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).543 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.1%
Citations provided by BIP!Popularity provided by BIP!