Ginkgolide A, B, and huperzine A inhibit nitric oxide production from rat C6 and human BT325 glioma cells.
Copyright policy )Ginkgolide A, B, and huperzine A inhibit nitric oxide production from rat C6 and human BT325 glioma cells.
To study the effects of ginkgolide A, B (Gin A, Gin B) and huperzine A (Hup A) on nitric oxide (NO) production from cultured astrocytes.Nitrites in supernatants were measured with Griess assay.Hup A 0.001-100 mumol.L-1 time- and concentration-dependently inhibited the NO production from rat C6 astrocytoma cells. The NO production from C6 cells was concentration-dependently inhibited by the treatment with Gin A or Gin B 0.001-10 micromol.L-1 for 24 h. The NO production from human BT325 astrocytoma cells was concentration-dependently inhibited by Hup A, Gin A, or Gin B 0.01-10 micromol.L-1 for 24 h.Gin A, Gin B, and Hup A inhibited astrocytes producing NO.
- Shanghai Institute of Materia Medica China (People's Republic of)
- Chinese Academy of Sciences China (People's Republic of)
Dose-Response Relationship, Drug, Brain Neoplasms, Glioma, Astrocytoma, Nitric Oxide, Rats, Lactones, Alkaloids, Ginkgolides, Neuroprotective Agents, Tumor Cells, Cultured, Animals, Humans, Diterpenes, Sesquiterpenes
Dose-Response Relationship, Drug, Brain Neoplasms, Glioma, Astrocytoma, Nitric Oxide, Rats, Lactones, Alkaloids, Ginkgolides, Neuroprotective Agents, Tumor Cells, Cultured, Animals, Humans, Diterpenes, Sesquiterpenes
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