Aspects of the transport and delivery of antisense oligonucleotides.

R L, Juliano; H, Yoo

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Article . 2001

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Aspects of the transport and delivery of antisense oligonucleotides.

descriptionPublicationkeyboard_double_arrow_right Article 12 Apr 2001 English Journal:Current opinion in molecular therapeutics, volume 2 (issn: 1464-8431,

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Authors: R L, Juliano; H, Yoo;

pmid: 11249624

Aspects of the transport and delivery of antisense oligonucleotides.

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Abstract

This article will examine recent developments concerning the cellular uptake and subcellular trafficking of antisense oligonucleotides. It will also examine the merits of various delivery strategies for oligonucleotides. The use of conjugates of oligonucleotides with 'cell penetrating peptides' as a promising delivery technology will be emphasized.

Related Organizations

University of North Carolina at Chapel Hill
United States

Keywords

Drug Delivery Systems, Lipid Bilayers, Administration, Oral, Animals, Biological Availability, Biological Transport, Active, Humans, Oligonucleotides, Antisense, Carrier Proteins

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