Application of ozone therapy was based on the notions of a significant role of lipid peroxidation in the pathogenesis of migraine attacks. A therapy was performed in form of intravenous infusions of the ozonized physiologic solutions with ozone, concentration 1200 micrograms/l; a therapy course included 8-9 procedures. 68 patients with migraine attacks, followed by the pronounced autonomic changes, that developed in the frequency range from 5-6 times a year to 2-3 times a week were examined. 40 patients formed a study group and 28 individuals control one (in a control group the physiologic solution was used without ozone). The intensity of a headache, the expression of an anxiety, the state of the vessels of the brain and some biochemical indices were determined. Positive dynamics of the disease was 25% higher in the study group than made up a those in the controls (p < 0.05). In 58% of the patients the attacks were absent during 3-5 months after ozone therapy; less intensity of headache was observed after their relapse. Improvements in the patients coincides with changes in biochemical parameters.