COVID-19 is a highly contagious disease first identified in December 2019 and has caused a pandemic of respiratory illness. During a global public health crisis like this one, health communication serves an instrumental role in controlling the spread of the virus. This entry provides a brief overview of the public health communication practices in the midst of the pandemic. Specifically, we focus on public health messaging in relation to the nature of the disease and mitigation measures in North America, Asia, and Europe. We identify several communication challenges during the pandemic and offer recommendations for future communication.