Seventy-five patients (89 eyes) with corneal edema were treated with topical instillations of 5% hypertonic saline in a water soluble polymer solution (Adsorbonac). Ancillary therapy included glaucoma medications, IDU, corticosteroids, antibiotics and hydrophilic bandage lenses. The drops were instilled as frequently as required to maintain clarity, and visual acuity was utilized as the sole parameter of therapeutic efficacy. Primarily because of variations in etiology, concurrent therapy, and environmental factors, the results showed a high degree of individual variability. The therapy was uniformly well tolerated and a majority of patients demonstrated improvement in the visual acuity following use of the medication for a period of 3 months.