[Effect of cycloferon on the evolution of cervical and vaginal cancer in mice].
Copyright policy )[Effect of cycloferon on the evolution of cervical and vaginal cancer in mice].
7,12-dimethylbenz(a)anthracene (DMBA) was given by tampon intravaginally to 198 mice CBA (9 groups), twice a week, for 2 months, to induce cervical and vaginal tumors. Cycloferon (CF)--an interferon inductor--was injected in study group animals subcutaneously and/or introduced into the vagina by smear, in 2-month courses. CF was given during DMBA treatment or after it. Controls were injected saline solution, sc, and/or received placebo smears, i.v. The experiment was run for 6 months. Tumor incidence in controls was 35-70%. Carcinogenesis tended to slow down when CF was given during DMBA treatment. Neoplasia was found in 38-57%. More marked anticarcinogenic effect was registered in animals receiving CF on termination of DMBA application: tumor frequency dropped to 29-41%, with malignant tumor number significantly reduced.
Mice, Interferon Inducers, Vaginal Neoplasms, 9,10-Dimethyl-1,2-benzanthracene, Acridines, Animals, Anticarcinogenic Agents, Uterine Cervical Neoplasms, Female, Drug Administration Schedule
Mice, Interferon Inducers, Vaginal Neoplasms, 9,10-Dimethyl-1,2-benzanthracene, Acridines, Animals, Anticarcinogenic Agents, Uterine Cervical Neoplasms, Female, Drug Administration Schedule
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