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Působení genotoxického 2-nitrofluorenu a jeho metabolitů na DNA in vivo a sledování tohoto působení pomocí elektrochemických DNA biosenzorů in vitro

Name: Působení genotoxického 2-nitrofluorenu a jeho metabolitů na DNA in vivo a sledování tohoto působení pomocí elektrochemických DNA biosenzorů in vitro
Keywords: DNA damage detection, DNA adducts, nitrated polycyclic aromatic hydrocarbons, 2-nitrofluorene

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2017 Czech Republic Czech

Authors: Skalová, Š. (Štěpánka); Stávková, K.; Hájková, A.; Barek, J.; Fischer, J.; Wang, J.; Vyskočil, V.;

handle: 11104/0278068

Působení genotoxického 2-nitrofluorenu a jeho metabolitů na DNA in vivo a sledování tohoto působení pomocí elektrochemických DNA biosenzorů in vitro

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Abstract

This review is focused on genotoxic 2-nitrofluorene, which is a marker for the presence of nitrated polycyclic aromatic hydrocarbons, and summarizes the current knowledge about the negative effects of 2-nitrofluorene and its metabolites on living organisms, especially on their DNA. These findings obtained via in vivo investigations are compared with information obtained using electro-chemical DNA biosensors, which represent very promising in vitro alternative to the study of processes proceeding in living organisms during the interaction of their DNA with various xenobiotic compounds.

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Czech Republic

Related Organizations

Czech Academy of Sciences
Czech Republic
Academy of Sciences Library
Czech Republic

Keywords

DNA damage detection, DNA adducts, nitrated polycyclic aromatic hydrocarbons, 2-nitrofluorene

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