Laboratories performing clinical molecular diagnostic and cytogenetic testing require improved information systems to address their specialized data processing needs. We developed an application that automates result reporting, documents quality assurance information, and tracks specimens. While similar functionality was implemented in both the molecular diagnostic and cytogenetic modules, we present an outcome assessment of the cytogenetic laboratory's use of the system since it maintained a relatively constant number of personnel, test procedures, and samples over a three-year period. Upon implementation, significant reductions occurred in the time taken from receipt of sample to the release of the final report by 44% (P < 0.001) and 48% (P < 0.001) for peripheral blood and bone marrow samples, respectively. The number of cases processed per technologist increased by 26% (P = 0.017). We attribute these gains in quality improvement to the automation of clerical tasks and decision support provided by the information system.