
Flubendazol is a veterinary antiparasitic agent which acts toxically on both adult and larval stages of round worms. It is nearly insoluble in water and it influences not only the selection of the dosage form, but also its biological availability. Its solubility can be increased by adding solutizers and tensides, or by complex-formation with cyclodextrins. In the published experimental paper the method of complex-formation of flubendazol with 2-hydroxypropyl-beta-cyclodextrin was employed and the effect of temperature on the resultant solubility of the active ingredient was examined. The final dosage form was pellets produced with the use of the method of extrusion and spheronisation.
Cyclodextrins, Mebendazole, Solubility, Antinematodal Agents, Chemistry, Pharmaceutical, beta-Cyclodextrins, Pharmaceutic Aids, Temperature, 2-Hydroxypropyl-beta-cyclodextrin
Cyclodextrins, Mebendazole, Solubility, Antinematodal Agents, Chemistry, Pharmaceutical, beta-Cyclodextrins, Pharmaceutic Aids, Temperature, 2-Hydroxypropyl-beta-cyclodextrin
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