Gastric epithelial dysplasia represents the only true histological marker of gastric cancer. In this bringing up to date, such subject is reproposed in consideration of taking into account the most recent acquisitions, subdividing gastric dysplasia into two degrees only: moderate and severe. For the first time an immunophenotypic study is made by means of the evaluation of gastric-entero-pancreatic antigens, which better identify the evolutive potential of the two degrees of gastric dysplasia and, furthermore, the clinical development is evaluated, thus showing the necessity of a strict endoscopic surveillance of such lesion.