Wnt/beta-catenin signaling.
Copyright policy )Wnt/beta-catenin signaling.
The Wnt/Wingless signaling transduction pathway plays an important role in both embryonic development and tumorigenesis. beta-Catenin, a key component of the Wnt signaling pathway, interacts with the TCF/LEF family of transcription factors and activates transcription of Wnt target genes. Recent studies have revealed that a number of proteins such as, the tumor suppressor APC and Axin are involved in the regulation of the Wnt signaling pathway. Furthermore, mutations in APC or beta-catenin have been found to be responsible for the genesis of human cancers.
- University of Tokyo Japan
Genes, APC, Lymphoid Enhancer-Binding Factor 1, Molecular Sequence Data, Proteins, Zebrafish Proteins, DNA-Binding Proteins, Repressor Proteins, Wnt Proteins, Cytoskeletal Proteins, Embryonic and Fetal Development, Axin Protein, Neoplasms, Proto-Oncogene Proteins, Mutation, Trans-Activators, Animals, Humans, Amino Acid Sequence, Signal Transduction, Transcription Factors
Genes, APC, Lymphoid Enhancer-Binding Factor 1, Molecular Sequence Data, Proteins, Zebrafish Proteins, DNA-Binding Proteins, Repressor Proteins, Wnt Proteins, Cytoskeletal Proteins, Embryonic and Fetal Development, Axin Protein, Neoplasms, Proto-Oncogene Proteins, Mutation, Trans-Activators, Animals, Humans, Amino Acid Sequence, Signal Transduction, Transcription Factors
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