The study is a review paper about the development of antituberculous substances in the group of quinazoline derivatives. Most antituberculous compounds under study contain the pertinent pharmacophores in the functional groups and their antituberculous activity cannot be considered to be specific for quinazolines. Nevertheless, several groups of antituberculously effective quinazoline derivatives were found which do not contain the known pharmacophores of antituberculous activity. The substances are, on the rule, of medium activity, but the activity of some of them, evaluated in vitro, approaches that of commonly used antituberculous agents. They can thus initiate new research in this direction. The present paper is already the 12th communication in a series of review papers about substances with antituberculous activity.