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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
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Criopreservación de geles de plasma rico en plaquetas

Authors: Guzmán Valera, Amanda;

Criopreservación de geles de plasma rico en plaquetas

Abstract

(ES) El plasma rico en plaquetas (PRP) es un componente sanguíneo, obtenido por centrifugación de la sangre total. Contiene una elevada concentración de plaquetas, (4-6 veces valores normales). Su contenido granular abundante en factores tróficos ha propiciado su aplicación en áreas médicas como Oftalmología, Otorrinolaringología, Cirugía Maxilofacial y Traumatología, para acelerar la reparación y regeneración de distintos tejidos. Desde su primera utilización en 1980 para tratar úlceras cutáneas, el PRP ha encontrado una amplia gama de aplicaciones, desde el tratamiento de heridas quirúrgicas, afecciones musculoesqueléticas, quemaduras y la reparación de nervios periféricos. Muchas de estas aplicaciones han arrojado resultados muy prometedores. Nos planteamos analizar este producto, como preparación farmacéutica en forma de gel, pretendiendo desarrollar un protocolo de congelación viable y seguro para la criopreservación del gel de PRP, y comparando su contenido y comportamiento biomecánico con utilizando dos criopreservantes (trehalosa y dimetisulfóxido) y la liofilización. Encontrando resultados interesantes y prometedores a favor de la trehalosa. (EN) Platelet-rich plasma (PRP) is a blood component, obtained by centrifugation of whole blood. It contains a high concentration of platelets (4-6 times normal values). Its granular content abundant in trophic factors has led to its application in medical areas such as Ophthalmology, Otorhinolaryngology, Maxillofacial Surgery and Traumatology, to accelerate the repair and regeneration of different tissues. Since its first use in 1980 to treat skin ulcers, PRP has found a wide range of applications, from the treatment of surgical wounds, musculoskeletal conditions, burns and the repair of peripheral nerves. Many of these applications have shown very promising results. We plan to analyze this product, as a pharmaceutical preparation in gel form, aiming to develop a viable and safe freezing protocol for the cryopreservation of the PRP gel, and comparing its content and biomechanical behavior with using two cryopreservatives (trehalose and dimethysulfoxide) and lyophilization, finding interesting and promising results in favor of trehalose.

Keywords

HEMATOLOGIA, 3205.04, FACRMACOLOGIA, 3209.02

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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