
handle: 10953.1/1287
El clásico sistema renina angiotensina ha sido ampliamente estudiado como uno de los principales mecanismos reguladores de la presión arterial. el balance hidrico y electrolitico. Estudios más reciente han puesto de manifiesto la existencia de sistemas renina anglotensina completos en diferentes órganos, por lo que es posible hablar de sistemas renina angiotensina locales lo que ha permitido estudiar nuevas funciones. Hoy en día se conoce la implicación del sistema renina angiolensina en diferentes patologías más allá de la presión arterial. En el presente ltabaio se realiza una revisión bibliográfica en la que se analizan los aspectos clásicos del SRA desde su descubrimiento mostrando especial interés en su participación en diferentes patologias de elevada incidencia como el cáncer de mama y la demencia de tipo Alzheimer. De igualmodo se analiza el posible empico do alguno de los componentes del sistema rcnina-angiotcnsina como herramienta diagnóstica o posible diana terapéutica.
The classical. renin-angiotens in-system (RAS) has been studied as an important regula tory mechanisms for water and h1droelectrolyt e balance and blood pressure. Other local RAS have been found in most organs and tissues involved in serverak other functions . To data, it is known that the RAS participates in different pathologies beyon hypertenion.We review the literature concerning the basics of the RAS, showing particular interest in its participation in various diseases with high incidence such as breast cancer and Alzheimer type dementia .We also analyze the behavior and functions not only of the active peptide of the RAS, but also some of the1r proteolyt1c reulatory enzymes. We w1ll know not only the changes incurred during these patholog1es, but also the possibility of using any of these components as diagnostic tools or even as therapeut1c targets.
Fisiología Endocrina, Endocrinology, Fisiología Humana, Human Physiology, 2411.04, Área fisiología, Physiology Area, 2410.10
Fisiología Endocrina, Endocrinology, Fisiología Humana, Human Physiology, 2411.04, Área fisiología, Physiology Area, 2410.10
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