Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis.
Copyright policy )Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis.
Activity of the p38alpha MAP kinase is stimulated by various stresses and hematopoietic growth factors. A role for p38alpha in mouse development and physiology was investigated by targeted disruption of the p38alpha locus. Whereas some p38alpha(-/-) embryos die between embryonic days 11.5 and 12.5, those that develop past this stage have normal morphology but are anemic owing to failed definitive erythropoiesis, caused by diminished erythropoietin (Epo) gene expression. As p38alpha-deficient hematopoietic stem cells reconstitute lethally irradiated hosts, p38alpha function is not required downstream of Epo receptor. Inhibition of p38 activity also interferes with stabilization of Epo mRNA in human hepatoma cells undergoing hypoxic stress. The p38alpha MAP kinase plays a critical role linking developmental and stress-induced erythropoiesis through regulation of Epo expression.
- University of California, San Diego United States
Male, Mice, Knockout, Gene Expression, Anemia, Gestational Age, Hematopoietic Stem Cells, p38 Mitogen-Activated Protein Kinases, Mice, Inbred C57BL, Embryonic and Fetal Development, Mice, Gamma Rays, Stress, Physiological, Gene Targeting, Tumor Cells, Cultured, Animals, Humans, Erythropoiesis, Female, Mitogen-Activated Protein Kinases, Erythropoietin
Male, Mice, Knockout, Gene Expression, Anemia, Gestational Age, Hematopoietic Stem Cells, p38 Mitogen-Activated Protein Kinases, Mice, Inbred C57BL, Embryonic and Fetal Development, Mice, Gamma Rays, Stress, Physiological, Gene Targeting, Tumor Cells, Cultured, Animals, Humans, Erythropoiesis, Female, Mitogen-Activated Protein Kinases, Erythropoietin
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).314 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!