[Comparative clinical study on 5-FU concentrations for oral HCFU and i.v. 5-FU].
Copyright policy )[Comparative clinical study on 5-FU concentrations for oral HCFU and i.v. 5-FU].
Using the cross-over method, the same patients were administered continuous intravenous injections of 5-FU and HCFU, an oral derivative of 5-FU widely used for breast and colon cancer in Japan. The pharmacokinetics of 5-FU in blood of both drugs were then compared. The AUC of the 5-FU concentration in blood of the HCFU 100 mg group tended to be higher than that in the 5-FU 250 mg group and lower than that in the 5-FU 500 mg group. There was, however, no statistically significant difference between the HCFU and 5-FU 250 mg groups (p = 0.3274), or between the HCFU and 5-FU 500 mg groups (p = 0.1921).
- Chiba Cancer Center Japan
Survival Rate, Cross-Over Studies, Injections, Intravenous, Administration, Oral, Humans, Antineoplastic Agents, Breast Neoplasms, Female, Fluorouracil, Drug Administration Schedule
Survival Rate, Cross-Over Studies, Injections, Intravenous, Administration, Oral, Humans, Antineoplastic Agents, Breast Neoplasms, Female, Fluorouracil, Drug Administration Schedule
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