[Effect of ganglioside GM1 on the metabolism of Alzheimer amyloid beta-protein precursor].
Copyright policy )[Effect of ganglioside GM1 on the metabolism of Alzheimer amyloid beta-protein precursor].
To study the effect of GM1 ganglioside interfering the metabolism of amyloid beta-protein precursor (APP) on cells for exploring the relationship between GM1 and development of Alzheimer senile plaques and the other amyloidoses.GM1 influencing the metabolism of APP and the release of its metabolite secretory APP on human APP695 cDNA transfected cells were detected by metabolic radiolabeling. The affinity of GM1 and recombinant secretory APP was analyzed by Western blot and dot blot.GM1 specifically bound APP, and interfered the proteolysis of APP and inhibited the release of secretory APP on cells.The abnormal metabolism of GM1 may contribute to the aggregation and deposition of amyloid beta-protein in Alzheimer brains.
- Beijing Chao-Yang Hospital China (People's Republic of)
Amyloid beta-Protein Precursor, Alzheimer Disease, Humans, G(M1) Ganglioside
Amyloid beta-Protein Precursor, Alzheimer Disease, Humans, G(M1) Ganglioside
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).0 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!