Using a sample of 292 medical technologists surveyed over a three-year period, this study tested the hypothesis that job-loss insecurity and job-feature insecurity were related but distinguishable constructs. Factor analysis supported this hypothesis. In addition, each construct demonstrated a differential pattern to significant antecedents. Specifically, cross-training desire and organizational downsizing were positively related, while job satisfaction was negatively related, to job-loss insecurity. However, team participation and number of professional organization memberships were negatively related, while routine task was positively related, to job-feature insecurity. Study limitations and future research issues are discussed.