The article presents a short characteristic of the general therapeutic principles in intestinal diarrheal infections, the main of which are the following: early beginning, individual approach and complex therapy. Therapeutic schemes of the most frequent diseases are given. Special attention is paid to the great importance of rational bacterio-therapy in current treatment of acute intestinal diarrheal infections. Individual approach considers determination or supposition of disease etiology and clinical form before treatment, as well as evaluation of state pathogenesis taking into account the body physiologic specificity, severity and period of disease, possible complications and concomitant disease. Complex therapy supposes simultaneous effect on disease agent, several links of its pathogenesis, struggle with intoxication, restoration of the disturbed functions of organs and systems, increase in body defense, treatment of concomitant diseases.