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Scaffolds de PLLA con nanotubos de carbono

Authors: Martín Balllesteros, Julen;

Scaffolds de PLLA con nanotubos de carbono

Abstract

Resumen: el objetivo de este proyecto final de grado ha sido analizar el impacto de los Nanotubos de Carbono dePared Múltiple (MWCNTs) en la microestructura y la degradación in vitro de andamios porosos(Scaffolds en inglés) para la Ingeniería de Tejidos (IT), fabricados a base de PLLA (Poli-L-lactida) y partículas de nanohidroxiapatita (nHA). Para la fabricación se ha empleado la técnica de separación de fases inducida térmicamente (TIPS) mediante un liofilizador. Una vez obtenidos los andamios se ha realizado una degradación in vitro durante variassemanas y se han recogido datos como: cantidad de agua absorbida, variación de pH y la pérdida de masa. Posteriormente se ha realizado un análisis térmico diferencial (DSC) y se ha observado la microestructura en el Microscopio de Barrido Electrónico (SEM) de la universidad.

Abstract: the main objective of this final degree work is to analyse the impact of Multiwalled Carbon Nanotubes(MWCNTs)adhesion,in the microstructure and in vitro degradation of porous scaffolds, for tissue engineering,made from PLLA (Poly-L-lactic) and nanohydroxyapatite (nHA) particles. For this, Thermally Induced Phase Separation (TIPS) technique has been used.An in vitro degradation has been realized once the scaffolds obtained,during someweeks,taking some data such as: amount of water absorbed, pH variation and the loss of mass. Then, a Differential Calorimetry Scanning (DSC) has been done and the microstructure has been observed using the Electronic Scanning Microscopy (SEM) of the university.

Laburpena: gradu amaierako lan honen helburuaAniztun Hormako Karbono Nano-hodien (MWCNTs)gehiketa,ehunen ingeniaritzan egindako PLLA (Poli-L-lactida) eta nanohidroxiapatita(nHA)partikulez osatutakoaldamio porotsuen mikroegituran eta in vitroko degradazioan duen eraginaaztertzea izan da. Horretarako, termikoki eragindako fase bereizketa (TIPS) teknika erabili da, liofilizagailu baten bidez. Aldamioak behin lortuta, zenbaitasteko in vitro degradazioa egin da, hainbat datu hartuz, hala nola: xurgatutako ur kantitatea, pH-bariazioa eta galdutako masa. Ondoren, analisi termiko diferentziala (DSC) egin da eta unibertsitateko ekorkeka elektronikoko mikroskopioan (SEM) aztertu egin da.

Country
Spain
Keywords

Scaffolds, IT, in vitro degradation, ehunen ingeniaritza, tissue engineering, MWCNTs, nHA, degradación in vitro, in vitro degradazioa, PLLA

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
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Green