
handle: 10784/14933
El presente estudio tuvo como objetivo evaluar la actividad anti-Leishmania in vitro de los extractos de las hojas en agua, las hojas más tallos en agua y hojas en etanol obtenidos de Crescentia cujete y Piper aduncum, para esto, se calculó la citotoxicidad, que para todos los extractos fue alta (CL50: <100 μg/mL). Se determinó también la actividad anti-Leishmania y aunque los valores están dentro del rango de actividad alta (CE50: <25 μg/mL), al tener en cuenta los resultados bajos del índice de selectividad (IS), es posible afirmar que se debe es a la muerte de la células y por ende de los parásitos más no por la muerte de estos a causa de los extractos. En conclusión, los extractos presentan más citotoxicidad que actividad
The present study aimed to measure in vitro anti-Leishmania activity of leaf extract in water, leaves plus stems in water and leaves in ethanol obtained from Crescentia cujete and Piper aduncum, to achieve this, cytotoxicity was calculated which for all extracts it was high (LC50: <100 μg/mL). The anti-Leishmania activity was also determined and even though values are in the high activity range (EC50: <25 μg/mL), by taking into account low results of selectivity index (SI), it is possible to affirm that it is due to cell death, hence of parasites, although their death is not because of extracts. In conclusion, extracts present more cytotoxicity than activity
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Trabajo
Natural extracts, Actividad Anti-Leishmania, Piper aduncum, Genética vegetal, Cytotoxicity, Extractos naturales, Citotoxicidad, Antileishmanial activity, Extractos vegetales, Leishmaniasis, Crescentia cujete
Natural extracts, Actividad Anti-Leishmania, Piper aduncum, Genética vegetal, Cytotoxicity, Extractos naturales, Citotoxicidad, Antileishmanial activity, Extractos vegetales, Leishmaniasis, Crescentia cujete
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