[Glycopeptides].
Copyright policy )[Glycopeptides].
To review pharmacology, pharmacokinetic and therapeutic use of glycopeptides in intensive care units.Extraction from Medline database of French and English articles on glycopeptides and search along with major review articles.The collected articles were reviewed and selected according to their quality and originality. The more recent data were selected.Glycopeptides are bactericidal antibiotics which are only active against Gram positive species acting by inhibiting peptidoglycan synthesis. They had been in clinical use for almost 30 years without high-level resistance underlining. For ten years, there have been disturbing reports of first, resistance to vancomycin in enterococcal species and more recently in strains of Staphylococcus aureus by complex and large mechanisms of action. This new resistances may lead to a therapeutic impasse and a fatal issue for infected patients. The only response to this situation is the respect of prescription rules and the careful use of antibiotics.Considering their spectrum, glycopeptides are an antibiotic family which importance is fundamental to treat infected patients of intensive care units. Staff members of intensive care units are responsible for their good use.
- Marseille Public University Hospital System France
- Hôpital Nord France
Critical Care, Glycopeptides, Lipoglycopeptides, Membrane Proteins, Drug Resistance, Microbial, Carboxypeptidases, Gram-Positive Bacteria, Drug Utilization, Anti-Bacterial Agents, Bacterial Proteins, Depression, Chemical, Drug Design, Operon, Humans, Drug Interactions, Enzyme Inhibitors, Peptide Synthases, Infusions, Intravenous, Carbon-Oxygen Ligases, Gram-Positive Bacterial Infections
Critical Care, Glycopeptides, Lipoglycopeptides, Membrane Proteins, Drug Resistance, Microbial, Carboxypeptidases, Gram-Positive Bacteria, Drug Utilization, Anti-Bacterial Agents, Bacterial Proteins, Depression, Chemical, Drug Design, Operon, Humans, Drug Interactions, Enzyme Inhibitors, Peptide Synthases, Infusions, Intravenous, Carbon-Oxygen Ligases, Gram-Positive Bacterial Infections
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