Neuroendocrine differentiation in non-small cell lung carcinomas.
Copyright policy )Neuroendocrine differentiation in non-small cell lung carcinomas.
The immunohistochemical expression of ten neuroendocrine and neural differentiation-related antigens in 200 specimens from patients with surgically resected non-small cell lung carcinomas were evaluated. Poorly differentiated adenocarcinomas and undifferentiated large cell carcinomas showed the highest percentage of positive samples (30%-60%) for the markers evaluated with diffuse and intense immunostaining. Poorly differentiated squamous carcinomas bronchioalveolar adenocarcinomas, and giant cell carcinomas showed a lower percentage of positive samples (20%) with moderate immunostaining. Well differentiated tumors were very rarely positive for the neuroendocrine markers. It is concluded that neoplasms positive for the neuroendocrine markers can be considered as non-small cell carcinoma with neuroendocrine features, even if they do not have the histological appearance of neuroendocrine lung neoplasms.
Calcitonin, Serotonin, Lung Neoplasms, Vasopressins, Cell Differentiation, Immunohistochemistry, Carcinoma, Neuroendocrine, CD57 Antigens, Adrenocorticotropic Hormone, Neurofilament Proteins, Carcinoma, Non-Small-Cell Lung, Phosphopyruvate Hydratase, Chromogranins, Chromogranin A, Humans, Vimentin, Bombesin, Immunohistochemistry; Neuroendocrine marker; Non-small cell lung carcinomas;
Calcitonin, Serotonin, Lung Neoplasms, Vasopressins, Cell Differentiation, Immunohistochemistry, Carcinoma, Neuroendocrine, CD57 Antigens, Adrenocorticotropic Hormone, Neurofilament Proteins, Carcinoma, Non-Small-Cell Lung, Phosphopyruvate Hydratase, Chromogranins, Chromogranin A, Humans, Vimentin, Bombesin, Immunohistochemistry; Neuroendocrine marker; Non-small cell lung carcinomas;
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