Management of pain, and complete elimination of infection preceding an endodontic treatment has always been a challenge to practitioners. The best of an endodontic treatment is achieved by means of successful management of pre- and post- endodontic treatment pain and eradication of any possible infection. This article reviews the pharmacodynamics comparison of non-steroidal and steroidal drugs, as a potentially successful analgesic, and efficiency of antibiotics based on recent bacterial susceptibility tests, for an effective endodontic treatment with minimal side-effect liability.

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