Studies on muscarinic M2 receptors in smooth muscle.
Copyright policy )Studies on muscarinic M2 receptors in smooth muscle.
Histamine after M3 receptor alkylation with 4-DAMP mustard does not serve simply as a spasmogen but facilitates visualization of the M2-mediated contraction induced by oxotremorine M. We speculate that M3 receptor activation has a similar role in untreated tissue. The facilitation appears to involve protein kinase C. The results with propranolol suggest that the phospholipase D pathway may also be important in the development of the M2-mediated response.
- Monash University Australia
Receptor, Muscarinic M3, Receptor, Muscarinic M2, Muscle Relaxation, Oxotremorine, Adrenergic beta-Antagonists, Guinea Pigs, Isoproterenol, Muscle, Smooth, Adrenergic beta-Agonists, In Vitro Techniques, Muscarinic Agonists, Propranolol, Receptors, Muscarinic, Muscle Tonus, Animals, Cecum, Histamine, Muscle Contraction
Receptor, Muscarinic M3, Receptor, Muscarinic M2, Muscle Relaxation, Oxotremorine, Adrenergic beta-Antagonists, Guinea Pigs, Isoproterenol, Muscle, Smooth, Adrenergic beta-Agonists, In Vitro Techniques, Muscarinic Agonists, Propranolol, Receptors, Muscarinic, Muscle Tonus, Animals, Cecum, Histamine, Muscle Contraction
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