Correlation between cytochrome P-450 CYP2D6 (CYP2D6) genotype and phenotype.
Copyright policy )Correlation between cytochrome P-450 CYP2D6 (CYP2D6) genotype and phenotype.
To study the correlation between CYP2D6 genotype and its phenotype.CYP2D6 genotyping was made by detecting CYP2D6*3, *4, *6, and *7 alleles with an allele-specific polymerase chain reaction procedure.The CYP2D6 genotypes were well correlated with its phenotypes in all 125 extensive metabolizers and in 43 poor metabolizers. Extensive metabolizers had at least one wildtype CYP2D6 gene and the genotypes were *1/*1, *1/*3, and *1/*4. Poor metabolizers were found to be homozygous mutants of CYP2D6 gene and the genotypes were *3/*4, *4/*4, *3/*6, *4/*7, *4/*6, and *6/*6.Genotype could be used to screen variations of CYP2D6 expression.
- Zhejiang Ocean University China (People's Republic of)
Adult, Male, Phenotype, Cytochrome P-450 CYP2D6, Genotype, Humans, Female, Middle Aged, Polymerase Chain Reaction, Alleles
Adult, Male, Phenotype, Cytochrome P-450 CYP2D6, Genotype, Humans, Female, Middle Aged, Polymerase Chain Reaction, Alleles
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