Estudio longitudinal del síndrome metabólico tras el trasplante renal
Estudio longitudinal del síndrome metabólico tras el trasplante renal
Introducción: La aparición del síndrome metabólico (SM) entre los receptores renales es una de la mayores complicaciones postrasplante y se asocia con un mayor riesgo de fracaso del injerto y altas tasas de obesidad y diabetes de nueva aparición. Objetivos: Este estudio tiene como objetivo investigar la prevalencia y factores de riesgo asociados al desarrollo del SM y evaluar la asociación del mismo con la disfunción del injerto. Métodos: La muestras estuvo formada por 138 pacientes trasplantados renales, 83 hombres y 55 mujeres, trasplantados renales, que asistieron durante cinco años a la consulta postrasplante. Se analizaron como posibles factores de riesgo para DMPT: edad, sexo, índice de masa corporal (IMC), peso, hipertensión, diabetes, LDL, HDL, triglicéridos en suero y terapia inmunosupresora (Ciclosporina, tacrolimus, micofenolato mofetil), también se evaluó la prevalencia de episodios de rechazo agudo y función renal. Resultados: La prevalencia de SM fue del 39,85%. Como factores de riesgo estadísticamente significativos se obtuvieron el IMC, sobrepeso, niveles colesterol HDL, triglicéridos y LDL así como la hipertensión y la diabetes. Se obtuvieron altas tasas de rechazo agudo y diferencias en cuento a la tasa de filtración glomerular. Conclusiones: Existe una alta prevalencia del SM que compromete gravemente la funcion renal y la supervivencia del injerto en pacientes trasplantados renales, Es importantisimo el control y seguimiento estricto de todos los factores de riesgo identificados.
Índice de Masa Corporal, Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Immunologic Factors::Immunosuppressive Agents, Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression, Obesidad, Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged, Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Body Mass Index, Kidney transplantation, Síndrome Metabólico, Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Membrane Transport Modulators::Calcium Channel Blockers, Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Metabolic Syndrome X, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Renal Replacement Therapy::Kidney Transplantation, Obesity, Metabolic Syndrome, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence, Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Causality::Risk Factors, Medical Subject Headings::Check Tags::Female, Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Transplantation Immunology::Host vs Graft Reaction::Graft Rejection, Medical Subject Headings::Chemicals and Drugs::Lipids, Medical Subject Headings::Check Tags::Male, Trasplante renal, Dislipemia, Dyslipidemia, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis::Kaplan-Meier Estimate, Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Postoperative Complications
Índice de Masa Corporal, Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Immunologic Factors::Immunosuppressive Agents, Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression, Obesidad, Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged, Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Body Mass Index, Kidney transplantation, Síndrome Metabólico, Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Membrane Transport Modulators::Calcium Channel Blockers, Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Metabolic Syndrome X, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Renal Replacement Therapy::Kidney Transplantation, Obesity, Metabolic Syndrome, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence, Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Causality::Risk Factors, Medical Subject Headings::Check Tags::Female, Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Transplantation Immunology::Host vs Graft Reaction::Graft Rejection, Medical Subject Headings::Chemicals and Drugs::Lipids, Medical Subject Headings::Check Tags::Male, Trasplante renal, Dislipemia, Dyslipidemia, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis::Kaplan-Meier Estimate, Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Postoperative Complications
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